TABLE 1.

Naloxone Formulations and Features

	Injectable (and Nasal) Generic	Intranasal Branded	Injectable Generic	Auto-injector Branded
FDA approval	X (for IV, IM, SC)	X	X	X
Layperson experience	X		X	X
Fragile; requires assembly	X		X
Can titrate dose	X		X
Strength	1 mg/mL	4 mg/0.1 mL	0.4 mg/mL or 4 mg/10 mL	0.4 mg/0.4 mL
Cost per kit	$$	$$	$	$$$
Rx and quantity	#2, 2 mL Luer-Jet Luer-Lock needleless syringe plus #2 mucosal atomizer devices (MAD-300)	#1 two-pack of two 4-mg/0.1 mL intranasal devices	#2 single-use 1-mL vials or #1 10-mL multidose fliptop vial PLUS #2 3 mL syringe with 23 to 25 gauge 1–1.5 inch IM needles	#1 two-pack of two 0.4 mg/0.4 mL prefilled auto-injector devices
Sig. (for suspected opioid overdose)	Spray 1 mL (1/2 of syringe) into each nostril. Repeat after 2 to 3 minutes if no or minimal response	Spray 0.1 mL into one nostril. Repeat with second device into other nostril after 2 to 3 minutes if no or minimal response	Inject 1 mL in shoulder or thigh. Repeat after 2 to 3 minutes if no or minimal response	Inject into outer thigh as directed by English voice-prompt system. Place black side firmly on outer thigh and depress and hold for 5 seconds. Repeat with second device in 2 to 3 minutes if no or minimal response

Some portions developed with funding from NIDA R01 DA034634.