Coefficient	p	95% CI
Gradual responders
Intercept	4.06	< 0.001	3.92; 4.20
Time	− 0.69	< 0.001	− 0.88; − 0.50
Time2	0.28	< 0.001	0.19; 0.37
Time3	− 0.03	< 0.001	− 0.05; − 0.02
Rapid responders
Intercept	5.83	< 0.001	5.47; 6.34
Time	− 2.63	< 0.001	− 3.32; − 1.94
Time2	0.81	< 0.001	0.47; 1.15
Time3	− 0.08	< 0.001	− 0.12; − 0.3
Inadequate responders
Intercept	5.14	< 0.001	4,53; 5.75
Time	3.68	< 0.001	2.46; 4.90
Time2	− 1.51	< 0.001	− 2.09; − 0.93
Time3	0.17	< 0.001	0.09; 0.25