Table 2.
Multivariate association of the 10-miRNA classifier, clinicopathological characteristics with DRFS.
| Variable | Cohort 1 (n = 303) |
Cohort 2 (n = 152) |
Cohort 3 (n = 156) |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| 10-miRNA classifier (High vs. Low risk) | 11.04(6.26–19.49) | < 0.0001 | 4.95(2.51–9.74) | < 0.0001 | 5.65(2.38–13.42) | < 0.0001 |
| Age (> 40 years vs. ≤ 40 years) | 0.86(0.44–1.65) | 0.642 | 1.04(0.47–2.28) | 0.926 | 0.65(0.20–2.13) | 0.474 |
| Menopause(Yes vs. No) | 0.85(0.46–1.56) | 0.588 | 0.76(0.37–1.56) | 0.455 | 0.41(0.16–1.04) | 0.061 |
| T stage ( ≤ 2 cm vs. > 2 cm) | 1.80(0.82–3.99) | 0.145 | 2.29(0.74–7.06) | 0.15 | 1.37(0.07–26.02) | 0.836 |
| LN (positive vs. negative) | 2.14(1.02–4.48) | 0.044 | 1.96(0.98–3.91) | 0.058 | 1.51(0.22–10.51) | 0.678 |
| TNM stage ( III–II vs. I) | 1.93(0.35–10.75) | 0.452 | 2.82(0.34–23.19) | 0.336 | 2.65(0.11–63.06) | 0.546 |
| Grade ( III–II vs. I) | 2.18(0.50–9.55) | 0.303 | 3.06(0.70–13.43) | 0.139 | 1.10(0.45–9.02) | 0.927 |
| Ki67(> 14% vs. ≤ 14%) | 1.62(0.85–3.10) | 0.143 | 1.09(0.56–2.13) | 0.801 | 2.90(1.04–8.09) | 0.042 |
| Chemotherapy (yes vs. no) | 0.56(0.32–0.98) | 0.042 | 0.52(0.26–1.02) | 0.058 | 0.44(0.19–1.06) | 0.068 |
DRFS = disease relapse free survival; and LN = lymph node.