Appendix 1—table 4.

Parameter set used in tunnel analysis using CAVER3.0 (Chovancova et al., 2012) and CAVER Analyst1.0 (Kozlikova et al., 2014).

DOI: http://dx.doi.org/10.7554/eLife.17505.039

Minimum probe radius	0.9 Å
Shell depth	4
Shell radius	3
Clustering threshold	3.5
Starting point optimization
Maximum distance	3 Å
Desired radius	5 Å