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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Apr 4;8(6):814–841. doi: 10.1002/wnan.1400

Figure 10.

Figure 10

Examples of stimuli-repsonsive MRI contrast agents. H2O2 responsive contrast agent: (A) Schematic representation of activation by hydrogen peroxide: gadolinium oxide nanoparticles (purple spheres) were released upon polymer degradation triggered by hydrogen peroxide. pH responsive contrast agent: (B) Representation showing the core MnO content unloading from the urchin-shaped MnO@Mn3O4 nanoparticle at low pH. (C) Magnetic resonance images of leached out MnII ions from pH 5 PBS buffer (color coded). (D) Temporal color-coded T1-ultrashort echo time MR images of a tumor after intravenous injection of hollow MnO@Mn3O4 nano-urchin. (Reproduced with permission from 84 and 86. Copyright 2013 American Chemical Society and 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)