CEST of Ln (III) chelates anchored on the surface of mesoporous silica nanoparticles. (A) T2w, (B) T1w, and (C)–(E) STmap at 5.5 ppm, 7.5 ppm and 15 ppm, respectively; Labeled capillary positions 1–5 correspond to (1) GdDO3A–MCM-41, (2) EuDO3A–MCM-41, (3) TmDO3A–MCM-41, (4) TbDO3A–MCM-41, (5) unlabeled MCM-41; Schematic representation of: (F) the interaction between LnDO3A-like chelates and the surface of the organo-modified MCM-41; (G) Ln (III) chelates anchored on organo-modified mesoporous silica nanoparticles. (Reproduced with permission from 111. Copyright 2014 The Royal Society of Chemistry)