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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Clin Cancer Res. 2016 May 3;22(19):4890–4900. doi: 10.1158/1078-0432.CCR-15-2823

Figure 4. Docetaxel Treatment Increases Nociceptive Sensitivity in VAC14 Heterozygous and Wild-type Mice.

Figure 4

The withdrawal threshold is defined as the lightest fiber weight that caused each mouse to withdraw their hind paw at least three times out of five. Each mouse has a withdrawal threshold at each time-point in the study. The mean withdrawal threshold is the average of 12-14 mice (6-7 for each gender) for each treatment condition (VAC14 genotype and docetaxel treatment). Docetaxel- treated mice of either genotype had greater hindpaw withdrawal sensitivity following the end of treatment at day 8 compared to the untreated control mice (p<0.0001). There was no significant difference in the docetaxel-induced increase in withdrawal sensitivity comparing VAC14 heterozygous and wild-type mice (p=0.18).