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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Biol Psychiatry. 2016 May 6;80(9):652–660. doi: 10.1016/j.biopsych.2016.04.020

Figure 1. Withdrawal from cocaine self-administration increases p-SMAD3 and BRG1 protein levels and interaction.

Figure 1

(A) Timeline of behavioral testing and tissue collection. (B) Mean number of saline and cocaine (1 mg/kg/inf) infusions per session during self-administration training (n = 6/group). (C) Representative anatomical location of tissue punches taken from rat nucleus accumbens (NAc) and caudoputamen (CPU). (D–G) Relative p-SMAD3 and BRG1 expression in the NAc (D, E; n = 6/group) and CPU (F, G; n = 5–6/group). Data are expressed as mean ± SEM; *P < 0.05 vs. saline. Sal = saline; Coc = cocaine.