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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2016 May 9;31:1–15. doi: 10.1016/j.cytogfr.2016.05.001

Figure 4. Mechanism of the STAT3 anti-inflammatory response.

Figure 4

Activation of STAT3 by IL-6R or IL-10R (not shown) inhibits expression of Ube2n/Ubc13, thereby restraining TLR4 signal transduction via NF-κB and MAP kinase (not shown) cascades.