Table 1.
Baseline Characteristics by Hp genotype
| HP 1-1 or HP 2-1 (N=787) |
HP 2-2 (N=516) |
p-value* | |
|---|---|---|---|
| Intensive treatment group | 399 (51) | 237 (46) | 0.092 |
| Age (years) | 27 ± 7 | 27 ± 7 | 0.667 |
| BMI (kg/m2) | 23.4 ± 2.8 | 23.4 ± 2.8 | 0.730 |
| Duration of type 1 diabetes in months | 66 ± 49 | 70 ± 51 | 0.259 |
| Female | 379 (48) | 230 (45) | 0.205 |
| Baseline HbA1c (%) | 8.8 ± 1.5 | 8.9 ± 1.6 | 0.104 |
| Baseline HbA1c (mmol/mol) | 72.7 ± 16.9 | 74.3 ± 17.6 | 0.104 |
| Primary cohort | 402 (51) | 249 (48) | 0.319 |
| Clinical neuropathy = yes | 48 (6) | 32 (6) | 0.958 |
| Smoker = yes | 145 (18) | 101 (20) | 0.604 |
| LDL (mg/dL) | 108 ± 29 | 111 ± 30 | 0.082 |
| HDL (mg/dL) | 50 ± 12 | 50 ± 12 | 0.652 |
| Triglycerides (mg/dL) | 82 ± 49 | 82 ± 48 | 0.682 |
| Cholesterol (mg/dL) | 175 ± 33 | 178 ± 35 | 0.132 |
| Blood pressure (mm Hg) | |||
| Systolic | 114 ± 12 | 115 ± 11 | 0.171 |
| Diastolic | 73 ± 9 | 72 ± 9 | 0.990 |
| Estimated Glomerular Filtration Rate (mL/min/1.73m2) |
125.5 ± 14.0 | 126.0 ± 13.3 | 0.441 |
| Albumin excretion rate (mg/24 h) | 15.8 ± 17.3 | 15.9 ± 20.8 | 0.862 |
Data are N (%) and mean ± SD.
*
Wilcoxon for continuous variables and chi-square test for categorical variables.