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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Cancer Res. 2016 Aug 16;76(19):5671–5682. doi: 10.1158/0008-5472.CAN-16-0144

Figure 7. A model describing the CCL2-CCR4/2 axis in GBM.

Figure 7

Glioma-derived CCL20 and OPG induces the production of CCL2 from glioma-associated macrophages and microglia. CCL2 recruits CCR4-expressing Tregs and CCR2-expressing monocytes to GBM. These monocytes then differentiate into CCR2+ MDSCs.