Table 4.

Unadjusted and Adjusted Hazard Risk of Pediatric AML Mortality Associated with Socio-economic Factors and Clusters, SEER 1973–2012

	Unadjusted Analysis		Adjusted Analysis
Variables	HR (95% CI)	p-value	HR (95% CI)	p-value
SES Factors
Factor 1	1.08 (1.03, 1.13)	0.002	1.07 (1.02, 1.12)	0.005
Factor 2	1.00 (0.95, 1.05)	0.95	0.99 (0.94, 1.04)	0.69
Factor 3	1.05 (1.00, 1.10)	0.04	1.05 (1.00, 1.10)	0.06
Factor 4	0.99 (0.95, 1.04)	0.82	0.98 (0.93, 1.03)	0.48
SES Clusters
Cluster 1	1.00	-	1.00	-
Cluster 2	1.15 (0.96, 1.37)	0.13	1.13 (0.94, 1.37)	0.20
Cluster 3	1.23 (1.04, 1.46)	0.02	1.19 (1.00, 1.42)	0.05
Cluster 4	1.09 (0.9, 1.32)	0.36	1.10 (0.9, 1.34)	0.37
Cluster 5	1.11 (0.96, 1.29)	0.16	1.13 (0.97, 1.31)	0.10
Cluster 6	1.26 (1.03, 1.54)	0.02	1.23 (1.01, 1.51)	0.04
Cluster 7	1.05 (0.89, 1.23)	0.59	1.04 (0.88, 1.23)	0.64

Note: AML: Acute Myeloid Leukemia; HR: Hazards Ratio; CI: Confidence Interval; Adjusted models controlled for the following prognostic indicators: age at diagnosis, race-ethnicity, sex, US region and AML subtypes