FIGURE 2.

Blood clearance of ²²⁵Ac-E4G10 and ²²⁵Ac-isotype control in glioblastoma-bearing (A) and naïve Ntva (B) mice. Green circles indicate ²²⁵Ac-E4G10 and blue triangles ²²⁵Ac-isotype. Reported values are percentage injected dose per gram (%ID/g). Glioblastoma ± brain-to-blood ratio (C) and bone-to-blood ratio (D) illustrate accumulation of ²²⁵Ac-E4G10 in tumor and red bone marrow tissue. Relative ratios of glioblastoma ± brain normalized to blood and bone normalized to blood are displayed. Green solid line is ²²⁵Ac-E4G10 in glioblastoma mice, green dashed line is ²²⁵Ac-E4G10 in naïve mice, blue solid line is ²²⁵Ac-isotype in glioblastoma mice, and blue dashed line is ²²⁵Ac-isotype in naïve mice. GBM = glioblastoma.