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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Aug 25;26(20):5087–5091. doi: 10.1016/j.bmcl.2016.08.080

Table 3.

Antiviral Activity of select pyrimidines against BK Virus in human foreskin fibroblasts

Cmpd EC50 (μM)a CC50 (μM)a
BQU015242 3.9 ± 4.0b >67 ± 46b
SMAL 1.7 ± 0.76 20 ± 17.8
AMT580-043 1.8 ± 0.86 17 ± 1.7
Cidofovir 1.1 ± 1.2 >100 ± 0
a

Values shown represent the average EC50 value and CC50 value from three independent experiments ±SD.

b

Values shown are from two independent experiments. EC50: effective concentration at which 50% activity is evident; CC50: cytotoxic concentration to cause death in 50% of viable cells.