Table 1. Endpoint 90-day mortality.
| Variable | Hazard ratio (95% CI) | Regression coefficient | Standard error | P value |
|---|---|---|---|---|
| At admission | ||||
| APACHE II | 1.1231 (1.077–1.170) | 0.116100 | 0.021190 | <0.0001 |
| At 48 hours | ||||
| APACHE II | 1.0983 (1.039–1.160) | 0.093790 | 0.028120 | 0.0009 |
| MR-proADM 48 hours | 1.0756 (1.008–1.147) | 0.729000 | 0.033310 | 0.0286 |
| At 5th day | ||||
| Age | 1.0557 (1.056–1.108) | 0.054250 | 0.024950 | 0.0297 |
| Immunodeficiency | 4.2387 (1.257–14.29) | 1.444300 | 0.623300 | 0.0205 |
| MR-proADM 5th day | 1.2199 (1.102–1.350) | 0.198800 | 0.052040 | 0.0001 |
| CI MR-proADM 5th day | 0.9959 (0.993–0.998) | −0.004091 | 0.004091 | 0.0046 |
Multivariable analysis (Cox proportional hazards models): endpoint 90-day mortality (53). APACHE II, Acute Physiology and Chronic Health Evaluation II; MR-proADM, mid-regional pro-adrenomedullin; CI MR-proADM, mid-regional pro-adrenomedullin clearance.