Figure 1.

Candidate genes affecting antibody responses in sepsis. The series of events from antigen presentation to antibody production is shown. Implicated proteins are encoded by genes that bear SNPs that are candidate to modulate the production and function of IGs. IGs can feed back via the Fc component of IgG to modulate the state of activation or inhibition of antigen (Ag) presenting cells by interactions with Fc receptors. SNPs, single nucleotide polymorphisms; HLA, human leukocyte antigen II; IGs, immunoglobulins; Fc, crystallizable fragment of immunoglobulin; IL, interleukin; PRR, pattern recognition receptors; Th, T-helper; TNFα, tumor necrosis factor-alpha; Fab, fragment antibody binding; FcγR, Fc gamma receptor; TGFβ, transforming growth factor beta.