Table 1.

N. crassa strains used in this study and their susceptibility to ketoconazole (KTC).

Gene name	Annotation	Gene	Strain no.	Mating type	Susceptibility to KTC***
WT			FGSC#4200	a
hsp80	Heat shock protein 90	NCU04042	FGSC#11468	a, het*	++
			FGSC#11625	het	++
p23/sba1	Co-chaperone of HSP90	NCU01792	FGSC#11871	a	+++
			FGSC#11872	A	+++
aha1	Activator of HSP90 ATPase	NCU04087	FGSC#11561	A	+++
sti1	Stress inducible protein	NCU00714	FGSC#18705	A	+++
hsf1	Heat shock transcription factor	NCU08512	FGSC#14521	a, het	++
cna1	Calcineurin subunit A	NCU03804	FGSC#17929	a, het	+
			FGSC#11549	NA**	++
			FGSC#11550	NA	++
cnb1	Calcineurin subunit B	NCU03833	FGSC#12512	Het	+
			FGSC#12496	a, NA	+
			FGSC#15793	a, NA	+
cdc37	Cell division cycle 37	NCU00472	FGSC#16472	a, het	+
hsp70-1	Heat shock protein 70	NCU09602	FGSC#16015	a, het	−
hsp70-2	Heat shock protein 70	NCU02705	FGSC#13509	a, het	+
hsp70-3	Heat shock protein 70 cofactor	NCU01499	FGSC#14664	a	+
hsp88	HSP70 family, HSPA4-like	NCU05269	FGSC#11627	Het	−
hsp98	HSP110 family, HSP104-like	NCU00104	FGSC#11558	a	−
nup-17 (PPIase)	Cyclophilin 40 family	NCU03853	FGSC#11560	a	−
nup-5 (PPIase B)	Cyclophilin 40 family	NCU01200	FGSC#12036	a	+
nup-13 (PPIase H)	Cyclophilin 40 family	NCU02614	FGSC#11922	a	+
fkr-5 (PPIase FKBP-type)	FKBP52 family	NCU02455	FGSC#12999	a	−
crz1	Calcineurin-responsive zinc finger	NCU07952	FGSC#11494	a, het	−
Δp23Δsti1	double mutation	NCU01792, NCU00714	This study
Δp23Δaha1	double mutation	NCU01792, NCU04087	This study

^*het, heterokaryon;

^**NA, Not Available (in FGSC);

^***Susceptibility to 2 mg/L ketoconazole was measured by colony diameters, the diameters of wild type and tested strains were marked as R and r, “−” represents r ≈ R, “+” represents 50%R < r < R, “++” represents 0 < r < 50%R, and “+++” represents r ≈ 0.