Table 3.
Differential ontology classes at the protein-protein (PP) level for the sex-dependent genes.
| Ontology process (PP) | genes with sex ratio# < 1 | genes with sex ratio# >1 |
|---|---|---|
| Hypergeometric probability* | Hypergeometric probability* | |
| Anti-apoptotic mechanisms | 8.2 × 10−3 | 6.6 × 10−11 |
| Apoptotic mechanisms | 2.8 × 10−2 | 3.6 × 10−4 |
| Blood coagulation, platelet activation | 1.6 × 10−5 | 6.6 × 10−11 |
| NGFR signaling | 3.5 × 10−4 | 1.6 × 10−8 |
| FGFR signaling | 4.0 × 10−4 | 4.4 × 10−6 |
| Thyroid hormone receptor | 4.6 × 10−3 | 1.2 × 10−6 |
| Smoothened signaling | 1.9 × 10−1 | 4.1 × 10−3 |
| Superoxide formation/remotion | 8.9 × 10−2 | 4.0 × 10−3 |
| SWI/SNF complex, WINAC complex | 1.2 × 10−6 | 1.6 × 10−1 |
| Axogenesis, axon guidance | 1.1 × 10−4 | 6.3 × 10−5 |
| Schwann cell proliferation and differentiation | NDAS** | 1.0 × 10−3 |
| Pyramidal neuron development and differentiation | NDAS | 1.1 × 10−3 |
| Response to hypoxia | 7.7 × 10−2 | 3.0 × 10−4 |
| Response to insulin | 4.3 × 10−3 | 2.5 × 10−4 |
| mRNA processing and stability | 1.4 × 10−2 | 2.0 × 10−3 |
| mRNA splicing | 1.9 × 10−2 | 3.6 × 10−2 |
| mRNA silencing | NDAS | 8.5 × 10−3 |
| Steroid hormone signaling | 1.6 × 10−3 | 1.48 × 10−2 |
| Androgen receptor signaling | 6.4 × 10−3 | 1.6 × 10−1 |
| Complement activation, C3 membrane attack | 1.6 × 10−5 | 7.4 × 10−1 |
| Wnt receptor | 2.9 × 10−3 | 2.2 × 10−2 |
| beta-catenin-APC complex | 2.3 × 10−4 | NDAS |
| Non-canonical Wnt signaling | 1.3 × 10−1 | 3.8 × 10−2 |
| TGFbeta signaling | 6.3 × 10−3 | 1.7 × 10−4 |
| IL1-alpha | NDAS | 3.5 × 10−3 |
| IL-1 beta | 4.5 × 10−2 | NDAS |
| IL-1R antagonist | 8.4 × 10−3 | NDAS |
| Tumor Necrosis Factor | 3.5 × 10−1 | 3.1 × 10−3 |
| Mastocytes cytokine production | 4.0 × 10−3 | |
| Endothelial cell migration | 3.6 × 10−2 | 8.6 × 10−6 |
Functionalities are derived by ontology analysis of the compatible P-P networks computed on the basis of the corresponding Nucleus 1 from the whole set of specified genes (for details see the Table S4).
*
The hypergeometric probabilities are values corrected for the multi-comparisons. In addition, the values indicated are the averages of the probabilities along the several ontology categories that make up each sub-group defined, but weighed according to the relative frequency of the initial ontology classes that resulted from the analysis;
**
NDAS, no-detected as significant.