Table 5.
Disaggregation of effects of sex, age, and sex-age interaction on autophagy and its regulators.
| Interaction | Sex | Age | |
|---|---|---|---|
| TORC1 AND TORC2 COMPLEXES | |||
| Rheb | +3.53 | +1.29 | +1.68 |
| MTOR | −1.73 | ||
| RPTOR | +1.80 | ||
| AKT1S1 (PRAS40) | −1.40 | ||
| TTI2 | +1.56 | ||
| DEPTOR | +1.64 | −1.83//+1.30 | |
| RICTOR | +1.27//+1.36 | −1.37 | |
| MAPKAP1 (mSIN1) | +1.24 | ||
| PTEN | +2.1 | ||
| TSC1 | +1.19 | ||
| TSC2 | +1.21 | +1.25 | |
| PRKAA1 (AMPK) | −1.52 | ||
| PRKAA2 (AMPK) | +2 | ||
| AUTOPHAGIA (XENOPHAGIA, MICROPHAGIA) | |||
| ULK1 (ATG1) | −1.31 | ||
| ATG13 | +1.61 | ||
| ATG2A | +1.20 | ||
| ATG2B | +1.46 | +1.19 | |
| ATG4C | +1.45 | ||
| ATG4D | +1.24 | ||
| BECN1(ATG6) | +1.29 | ||
| BCL2 | −1.86 | +1.39 | |
| CALCOCO2 (NDP52) | −1.51 | ||
| MAP1LC3B1 (LC3) | −1.69 | ||
| MAP1LC3B2 (LC3) | −2 | ||
| LAMTOR3 | +1.55 | ||
| LAMTOR2 | +1.20 | ||
| LAMP1 | +1.48 | ||
| LAMP2 | −2.30 | ||
| LAMP5 | −1.33 | ||
| MITOPHAGY | |||
| PTEN | +2.1 | ||
| PINK1 | −2.65 | ||
| PARK2 | +2.1 | ||
| SMURF1 | −1.88 | ||
| HSPB8 | −2.63 | ||
| MFN1 (Mitofusin 1) | −1.27 | ||
| VDAC1 | +1.28 | ||
| VDAC3 | +1.93//+1.79 | ||
| BNIP3L | +1.18 | ||
| BNIP1 | +1.18 | ||
| RNF185 | +1.54 | +1.74 | |
| MAP1LC3A (LC3) | −1.69 | ||
| MAP1LC3B2(LC3) | −2 | ||
| TBK1 (TANK-binding Kinase 1) | −2.75 | ||
| HDAC6 | −1.94 | −1.52 | |