Fig. 1.

Behavioral changes due to administration of VE-deficient diet or RB-containing diet.

5%RB mice displayed increased movement behavior in the rotarod (A) and WRA tests (B) compared with the VEdef mice. Each group of mice NR (n = 6), VEdef (n = 4), 2%RB (n = 4) and 5%RB (n = 4) was subjected to the rotarod and WRA test. (A) Performance of each group of mice in the rotarod test. This score displays the mean of latency to fall. There is a significant difference between the VEdef and 5%RB mice at 3 months. (B) WRA was measured each month after the experiment started. There is a significant difference between VEdef and 5%RB mice at 3-months. *P < 0.05 vs. VEdef at same month (ANOVA). NR, normal diet alone; RB, rice bran; 2%RB, a mixture of vitamin E deficient feed and RB at a concentration 2% rice bran; 5%RB, a mixture of vitamin E deficient feed and RB at a concentration 5% rice bran; VE, vitamin E; VEdef, vitamin E-deficient feed; WRA, wheel running activity.