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. 2016 Oct 5;36(40):10337–10355. doi: 10.1523/JNEUROSCI.2160-16.2016

Figure 1.

Figure 1.

Er81 is expressed in nonmyelinating Schwann cells of Pacinian and Meissner corpuscles. A, Nuclear LacZ driven from the Er81 locus labels the nuclei of Er81+ cells. Anti-LacZ (green) immunostaining combined with anti-S100 (red) staining shows Er81 expression in the inner core Schwann cells of Pacinian corpuscles in whole-mount staining of the interosseous membrane at P7. B, Anti-LacZ and anti-S100 immunostaining of hindpaw glabrous skin sections from P21 Er81LacZ/+ mice shows expression of Er81 in the Schwann cells of Meissner corpuscle end organs. C, D, Anti-S100 and anti-NFH staining of paw glabrous skin sections from P21 Er81LacZ/+ control and Er81LacZ/LacZ null mice reveals no obvious deficit in the formation or innervation of Meissner corpuscles in Er81-nulls relative to controls. N = 3 animals per genotype. Scale bars: A, C, D, 20 μm; B, 5 μm.