Figure 7.

Cell death independent phenotype of Ret-null Pacinian corpuscles. A, B, H&E-stained sections of P0 Ret^CFP/+;Bax^−/− control (A) and Ret^CFP/CFP;Bax^−/− double-mutant (B) hindlimbs. Arrow indicates rudimentary Pacinian corpuscles, which are present in the Ret^CFP/+;Bax^−/− control but not Ret^CFP/CFP;Bax^−/− double-mutant hindlimbs. C, D, Anti-CFP staining of P0 Ret^CFP/+;Bax^−/− and Ret^CFP/CFP;Bax^−/− hindlimbs, which labels the axons of RA mechanoreceptors. Arrow indicates axons of interosseous nerve, which are absent in double mutants. T, Tibia; F, fibula. n = 2 animals per genotype. Scale bar, 50 μm.