Figure 9.

Er81 is not required for myelination of peripheral nerves. A, B, Transmission electron micrographs of L5 dorsal roots from P21 Er81^+/− control and Er81^−/− mutants reveal no defect in the morphology of the myelin sheath surrounding large-diameter sensory neurons in mutant mice. C, The g-ratios of myelinated axonal fibers are similar between Er81 mutants and controls (0.720 ± 0.007 in Er81^+/− controls, 0.7132 ± 0.006 in Er81^−/− mutants; p = 0.50). N = 3 animals per genotype, >100 fibers per animal. Scale bar, 2 μm.