Figure 7.

NS1619 attenuates the effect of METH on the spontaneous firing activity of dopamine neurons. A, Top, Representative trace from a spontaneously active dopamine neuron before and after application of METH followed by NS1619 treatment (10 μm). Bottom, Rate histogram of the trace above. B, C, Data are mean ± SEM; NS1619 diminished the effect of METH on the spontaneous firing frequency. D, E, Mean ± SEM; while METH increased the spike half-width, NS1619 attenuated the effect of METH on the spike half-width. F, Mean ± SEM; the coefficients of variation of the interspike intervals were not significantly different among the three groups: baseline, METH, and NS1619. In B, D, and F, the left y-axis shows absolute values, and the right y-axis shows normalized values. **p < 0.01 (n = 9 per group).