Figure 9.

Effects of T394A mutation on heroin-induced DA release in the NAc. A, Extracellular DA concentrations before and after 0.25 mg/kg and 1 mg/kg heroin injection in WT and T394A mutant mice. B, Heroin-induced changes in NAc DA normalized to baseline before heroin injection (% baseline). C, Representative brain section, showing path of a guide cannula and a microdialysis probe in the brain. D, Reconstruction of the placements of microdialysis probes in the brain, illustrating that active microdialysis membranes tended to span the length of the core and shell compartments of the NAc. *p < 0.05, compared with WT mice.