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. 2016 Sep 21;2016:9153673. doi: 10.1155/2016/9153673

Table 3.

Distribution of inflammatory biomarkers within upstream and downstream portions of carotid plaques.

Upstream Downstream p value
Neutrophil, cells/mm2 2.36 (0.93–5.93) 4.33 (1.20–10.68) 0.002
Total collagen, % 29.29 (18.28–38.57) 16.52 (8.39–22.11) <0.001
Collagen I, % 10.29 (5.37–15.20) 5.30 (2.39–8.23) <0.001
Collagen III, % 12.14 (8.20–18.23) 5.28 (2.93–8.98) <0.001
CRP, % 1.54 (0.61–2.78) 1.04 (0.44–2.18) 0.070
Smooth muscle cells, % 4.53 (3.01–9.00) 2.78 (1.53–4.27) <0.001
Total macrophages (CD68+), % 5.80 (2.72–10.23) 6.47 (2.24–13.94) 0.205
M1 subset (CD86+), % 1.33 (0.49–3.06) 3.21 (1.24–7.11) <0.001
M1 subset (HLA-DR+)§, % 10.47 (6.07–18.30) 9.50 (5.81–14.30) 0.124
M2 subset (CD163+), % 1.66 (0.56–3.83) 1.37 (0.22–3.30) 0.049

Data are expressed as median (interquartile range [IQR]).

CRP: c-reactive protein.

CD: cluster of differentiation.

M: macrophage.

§HLA-DR: human leukocyte antigen-antigen D related.