Table 4.

Correlation between intraplaque CRP and inflammatory biomarkers in upstream and downstream plaques.

Upstream			Downstream
CRP∗, % vs.	r	p value	CRP∗, % vs.	r	p value
Neutrophils/mm2	0.208	0.008	Neutrophils/mm2	0.087	0.275
Total collagen, %	0.063	0.430	Total collagen, %	−0.035	0.659
Collagen I, %	−0.008	0.918	Collagen I, %	−0.046	0.560
Collagen III, %	−0.138	0.082	Collagen III, %	−0.030	0.710
Smooth muscle cells, %	−0.315	<0.001	Smooth muscle cells, %	0.028	0.726
Total macrophages (CD68+)†, %	0.158	0.046	Total macrophages (CD68+)†, %	0.097	0.222
M‡1 subset (CD86+), %	0.113	0.151	M‡1 subset (CD86+), %	0.193	0.014
M1 subset (HLA-DR+)§, %	0.161	0.042	M1 subset (HLA-DR+)§, %	0.226	0.004
M2 subset (CD163+), %	0.031	0.694	M2 subset (CD163+), %	0.344	<0.001

Correlations were performed by Spearman's rank correlation coefficient.

^∗CRP: high sensitivity c-reactive protein.

^†CD: cluster of differentiation.

^‡M: macrophage.

^§HLA-DR: human leukocyte antigen-antigen D related.