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. 2016 Oct 5;6:34624. doi: 10.1038/srep34624

Figure 7. The ERK1/2 signaling pathway was activated in vitro and in vivo after GDF11 treatment.

Figure 7

(a,b) ERK1/2 phosphorylation and the expression of its downstream effectors c-Myc and cyclin D1 were increased in hPTCs treated with rGDF11, as shown by western blot. (c,d) ERK1/2 phosphorylation and the expression of its downstream effectors c-Myc and cyclin D1 were increased at 72 h after IRI in the kidneys of old mice treated with GDF11. For protein analysis (b), data are means ± SD from three independent experiments. *P < 0.05 vs. NC. For relative protein level determination (d), data are means ± SD; n = 3 in each group. OIC, old mice that underwent IRI for 28 min in the control group; OIG, old mice that underwent IRI for 28 min and were treated with GDF11. *P < 0.05 vs. OIC, **P < 0.01 vs. OIC. ##P < 0.01 vs. Sham.