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. 2016 Oct 5;6:34658. doi: 10.1038/srep34658

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Figure shows the TPMT phenotype frequency distribution for 524 paediatric patients, in the Wessex region (524 patients ≤ 18 years, between Dec 2010–April 2015, includes patients with/without IBD) and the TPMT phenotype distribution in our research cohort. Within our cohort we observe a statistically significant difference between the sub-category with TPMT values between 21–40 units (p = 0.001) compared to the Wessex paediatric population. This difference is not observed between the sub-categories with TPMT values between 41 to161 (p = 0.90)