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. 2016 Oct 5;6:34215. doi: 10.1038/srep34215

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The immunization regime and dosing schedule for Rhesus macaques vaccinated using tetravalent Dengue vaccine (Tetra DEN-80E) is depicted (a). Group numbers, number of animals per group and the test formulation administered to each group is specified in Fig. 6b. Tetra DEN-80E vaccine contains 10 μg, 10 μg, 10 μg, 20 μg, corresponding to DEN1/DEN2/DEN3/DEN4 serotypes respectively. Sera from immunized Rhesus macaques with specified test agents were collected at 0 hrs, 4 hrs, 8 hrs, and 24 hrs post dosing. Individual sera from each group were assayed in duplicates using the Luminex platform. The average value of each cytokine/chemokine from immunized animals at 0 hr (prebleed) time point was used to calculate the fold change. The fold change at 4 hrs, 8 hrs, and 24 hrs of individual animals are based on the heatmap color code depicted in Fig. 6c.