Table 2. MicroRNAs modulated in locally invasive breast tumors.
| Fold change (log2 RQ) | RQ-value | p-value | Locus | |
|---|---|---|---|---|
| Down-regulated miRNAs | ||||
| hsa-miR-204 | −4.87 | 0.0342 | 0.003 | 9q21.12 |
| hsa-miR-139-3p | −3.86 | 0.0691 | 0.005 | 11q13.4 |
| hsa-miR-125b-2* | −3.54 | 0.0859 | 0.038 | 21q21.1 |
| hsa-miR-486-5p | −3.53 | 0.0866 | 0.001 | 8p11.21 |
| hsa-miR-541 | −3.25 | 0.1054 | 0.032 | 14q32.31 |
| hsa-miR-216b | −3.04 | 0.1213 | 0.018 | 2p16.1 |
| hsa-miR-139-5p | −2.76 | 0.1481 | 0.001 | 11q13.4 |
| hsa-miR-489 | −2.60 | 0.1650 | 0.042 | 7q21.3 |
| hsa-miR-1 | −2.08 | 0.2373 | 0.021 | 20q13.33 |
| hsa-miR-335 | −2.04 | 0.2428 | 0.051 | 7q32.2 |
| hsa-miR-376c | −1.93 | 0.2623 | 0.009 | 14q32.31 |
| hsa-miR-132* | −1.89 | 0.2697 | 0.021 | 17p13.3 |
| hsa-miR-132 | −1.75 | 0.2973 | 0.010 | 17p13.3 |
| hsa-miR-369-3p | −1.73 | 0.3009 | 0.006 | 14q32.31 |
| hsa-miR-944 | −1.72 | 0.3028 | 0.025 | 3q28 |
| hsa-miR-488 | −1.66 | 0.3157 | 0.051 | 1q25.2 |
| hsa-miR-433 | −1.62 | 0.3247 | 0.006 | 14q32.2 |
| hsa-miR-424* | −1.60 | 0.3296 | 0.001 | Xq26.3 |
| hsa-miR-508-3p | −1.49 | 0.3566 | 0.030 | Xq27.3 |
| hsa-miR-218 | −1.49 | 0.3568 | 0.003 | 4p15.31 |
| hsa-miR-337-3p | −1.47 | 0.3612 | 0.044 | 14q32.2 |
| hsa-miR-10b* | −1.45 | 0.3648 | 0.001 | 2q31.1 |
| hsa-let7c | −1.42 | 0.3739 | 0.040 | 21q21.1 |
| hsa-let7b | −1.34 | 0.3962 | 0.038 | 22q13.31 |
| hsa-miR-376a | −1.32 | 0.4011 | 0.021 | 14q32.31 |
| hsa-miR-26b* | −1.29 | 0.4093 | 0.006 | 2q35 |
| hsa-miR-656 | −1.26 | 0.4161 | 0.018 | 14q32.31 |
| hsa-miR-95 | −1.26 | 0.4165 | 0.038 | 4p16.1 |
| hsa-miR-221* | −1.24 | 0.4243 | 0.016 | Xp11.3 |
| hsa-miR-543 | −1.20 | 0.4361 | 0.014 | 14q32.31 |
| hsa-miR-10b | −1.18 | 0.4420 | 0.015 | 2q31.1 |
| hsa-miR-100 | −1.18 | 0.4427 | 0.037 | 11q24.1 |
| hsa-miR-432 | −1.05 | 0.4816 | 0.035 | 14q32.2 |
| hsa-miR-195 | −1.03 | 0.4898 | 0.048 | 17p13.1 |
| Up-regulated miRNAs | ||||
| has-miR-155 | 11.91 | 3849.69 | 0.019 | 21q21.3 |
| hsa-miR-592 | 4.43 | 21.4937 | 0.003 | 7q31.33 |
| hsa-miR-638 | 3.14 | 8.8009 | 0.035 | 19p13.2 |
| hsa-miR-183* | 3.08 | 8.4533 | 0.005 | 7q32.2 |
| hsa-miR-21 | 2.73 | 6.6543 | 0.029 | 17q23.1 |
| hsa-miR-130b | 2.37 | 5.1594 | 0.044 | 22q11.21 |
| hsa-miR-142-3p | 2.26 | 4.7981 | 0.019 | 17q22 |
| hsa-miR-708 | 2.22 | 4.6601 | 0.049 | 11q14.1 |
| hsa-miR-181a* | 2.16 | 4.4810 | 0.044 | 1q32.1 |
| hsa-let7g* | 2.10 | 4.2809 | 0.004 | 3p21.1 |
| hsa-miR-148b* | 2.10 | 4.2749 | 0.010 | 12q13.13 |
| hsa-miR-18b | 1.80 | 3.4850 | 0.035 | Xq26.2 |
| hsa-miR-454* | 1.79 | 3.4608 | 0.007 | 17q23.2 |
| hsa-miR-7 | 1.71 | 3.2647 | 0.031 | 9q21.32 |
| hsa-miR-142-5p | 1.68 | 3.2130 | 0.039 | 17q22 |
| hsa-miR-431 | 1.60 | 3.0374 | 0.031 | 14q32.2 |
| hsa-miR-301a | 1.38 | 2.6071 | 0.024 | 17q22 |
| hsa-miR-188-5p | 1.32 | 2.5022 | 0.026 | Xp11.23 |
| hsa-miR-331-3p | 1.19 | 2.2822 | 0.003 | 12q22 |
| hsa-miR-425* | 1.18 | 2.2718 | 0.041 | 3p21.31 |