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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Science. 2016 Apr 29;352(6285):539–544. doi: 10.1126/science.aad9378

Fig. 3. Treg cells colonize the skin of neonatal mice and induce tolerance to commensal bacteria.

Fig. 3

Colonization of neonatal skin with a commensal microbiota leads to an accumulation of “activated” Treg cells (red cells) that specifically recognize an artificially marked antigen, with consequent tolerance to this same antigen in later life. Colonization of adult animals with the same microbiota containing the marked commensal microbiota (red triangle) does not lead to Treg cell accumulation in the skin or establish immune tolerance.