Table 1.
Minimal inhibitory concentrations (MIC) of ertapenem susceptible carbapenemase producing isolates
| Sample ID | ORGANISM | NDM | KPC | OXA-48 & variants | IMP | VIM | GES | Cefepime MIC | Cefotaxime MIC | Ceftazidime MIC | Ertapenem MIC | Imipenem MIC | Meropenem MIC | Doripenem MIC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ML0148.2 | Enterobacter cloacae | - | - | - | + | - | - | >16 | >32 | >16 | <=0.5 | <=2 | <=1 | Not tested |
| ML0191 | Klebsiella pneumoniae | - | - | - | - | - | + | 8 | >32 | >16 | <=0.5 | <=2 | <=1 | Not tested |
| ML0440 | Klebsiella pneumoniae | - | - | - | - | + | - | 16 | >32 | >16 | <=0.5 | 4 | 2 | Not tested |
| ML0446 | Klebsiella pneumoniae | - | - | - | - | + | - | <=1 | <=1 | <=1 | <=0.5 | <=2 | <=1 | Not tested |
| ML0848 | Klebsiella pneumoniae | - | - | - | - | + | - | >16 | >32 | >16 | <=0.5 | 4 | <=1 | <=1 |
| ML0917 | Providencia rettgeri | + | - | - | - | - | - | <=1 | <=1 | <=1 | <=0.5 | <=1 | <=1 | <=1 |
| ML0926 | Escherichia coli | + | - | - | - | - | - | <=1 | <=1 | <=1 | <=0.5 | <=1 | <=1 | <=1 |
| ML0930 | Klebsiella pneumoniae | - | - | - | - | + | - | >16 | >32 | >16 | <=0.5 | 4 | <=1 | <=1 |
| ML1002 | Providencia rettgeri | + | - | - | - | - | - | 8 | 32 | >16 | <=0.5 | >8 | 2 | 2 |
| ML1007 | Klebsiella pneumoniae | - | - | - | - | + | - | >16 | >32 | >16 | <=0.5 | 4 | <=1 | 2 |
| ML1161 | Klebsiella pneumoniae | - | - | + | - | - | - | >16 | >32 | >16 | <=0.5 | <=2 | <=1 | Not tested |
| ML1187 | Escherichia coli | - | - | + | - | + | - | 2 | 8 | 16 | <=0.5 | 4 | <=1 | <=1 |
| ML1189 | Klebsiella pneumoniae | - | - | - | - | + | - | >16 | >32 | >16 | <=0.5 | 2 | <=1 | <=1 |
| ML1219 | Klebsiella pneumoniae | - | - | - | - | + | - | 16 | >32 | >16 | <=0.5 | 2 | <=1 | <=1 |
| ML1279 | Klebsiella pneumoniae | - | - | - | - | + | - | >16 | >32 | >16 | <=0.5 | 2 | <=1 | <=1 |
| ML1296 | Klebsiella pneumoniae | - | - | - | - | + | - | >16 | >32 | >16 | <=0.5 | 4 | <=1 | <=1 |
| ML1340 | Morganella morganii | + | - | - | - | - | - | 8 | >32 | >16 | <=0.5 | 8 | <=1 | 2 |
| ML1354 | Klebsiella pneumoniae | - | - | - | - | + | - | >16 | >32 | >16 | <=0.5 | 4 | <=1 | 2 |
CLSI breakpoints: Cefepime: <=2 – Susceptible, 4-8 – Susceptible-Dose Dependant, > = 16 – Resistant; Cefotaxime: <=1 - Susceptible, 2 – Intermediate, > = 4 – Resistant; Ceftazidime: <=4 - - Susceptible, 8 – Intermediate, > = 16 – Resistant; Ertapenem: <=0.5- Susceptible, 1 – Intermediate, > = 2 – Resistant; Imipenem/Meropenem/Doripenem: <=1 – Susceptible, 2 – Intermediate, > = 4 Resistant [34]