TABLE 2.

Frequencies of monofunctional (IFN-γ⁺ or TNF-α⁺), bifunctional (IFN-γ⁺ TNF-α⁺), and multifunctional (IFN-γ⁺ TNF-α⁺ IL-2⁺) CD4⁺ T cells in ltLTBI and PTB

Antigen	Frequency (median [interquartile range]) (%)
	CD4+ IFN-γ+ T cells		CD4+ TNF-α+ T cells		CD4+ IFN-γ+ TNF-α+ T cells		CD4+ IFN-γ+ TNF-α+ IL-2+ T cells
	PTB	LTBI	PTB	LTBI	PTB	LTBI	PTB	LTBI
PPD	0.36 (0.09–0.40)	0.66 (0.25–1.13)a	1.41 (0.61–2.32)	3.32 (2.29–4.63)b	1.98 (0.52–3.61)	6.49 (4.69–11.59)b	0.00 (0.00–0.01)	0.00 (0.00–0.01)
RD1 antigens
E6-C10	0.11 (0.03–0.46)	0.38 (0.08–3.03)	0.46 (0.13–0.85)	1.14 (0.60–2.69)a	0.63 (0.24–2.30)	2.02 (0.77–7.05)a	0.00 (0.00–0.00)	0.00 (0.00–0.00)
DosR antigens
Rv1737c	0.06 (0.0–0.12)	0.06 (0.02–0.18)	0.18 (0.06–0.64)	0.41 (0.24–0.77)	0.15 (0.03–0.46)	0.24 (0.09–0.48)	0.00 (0.00–0.00)	0.00 (0.00–0.00)
Rv2029c	0.09 (0.05–0.18)	0.17 (0.07–0.46)	0.44 (0.18–0.73)	1.24 (0.59–1.97)c	0.60 (0.22–1.41)	1.29 (0.68–3.46)a	0.00 (0.00–0.00)	0.00 (0.00–0.00)
Rv2628	0.0 (0.0–0.02)	0.01 (0.0–0.04)	0.04 (0.01–0.11)	0.0 (0.0–0.03)	0.01 (0.00–0.02)	0.00 (0.0–0.01)	0.00 (0.00–0.00)	0.00 (0.00–0.00)
Rpf antigens
Rv0867c	0.06 (0.01–0.16)	0.11 (0.02–0.16)	0.52 (0.24–1.04)	0.95 (0.53–1.36)	0.35 (0.10–1.06)	0.50 (0.20–0.88)	0.00 (0.00–0.00)	0.00 (0.00–0.01)
Rv2389c	0.06 (0.00–0.23)	0.10 (0.06–0.18)	0.46 (0.22–0.68)	0.94 (0.34–1.39)a	0.28 (0.12–0.71)	0.45 (0.13–0.97)	0.00 (0.00–0.00)	0.00 (0.00–0.00)

^aP < 0.05.

^bP < 0.001.

^cP < 0.01.