TABLE 2.
HI antibody responses to 2014-2015 vaccine viruses in 3- to 17-year-old LAIV and IIV recipients
| Influenza virus strain and prevaccine HI titera | 2014-2015 LAIV (n = 97) |
2014-2015 IIV (n = 53) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of subjects (%) | Geometric mean titer (95% CI) |
% subjects with the following postvaccine HI titer: |
Fold rise | % Seroconversion | No. of subjects (%) | Geometric mean titer (95% CI) |
% subjects with with the following postvaccine HI titer: |
Fold rise | % Seroconversion | |||||
| Prevaccine | Postvaccine | ≥40 | ≥110 | Prevaccine | Postvaccine | ≥40 | ≥110 | |||||||
| A/California/07/2009 (A/H1N1) | ||||||||||||||
| All | 97 (100) | 54 (41–71) | 58 (45–75) | 69 | 37 | 1.1 | 3 | 53 (100) | 74 (51–106) | 246 (189–322) | 98 | 87 | 3.4 | 42 |
| HI < 40 | 31 (32) | 10 (8–13) | 13 (10–16) | 6 | 0 | 1.3 | 6 | 13 (25) | 10 (7–15) | 160 (65–394) | 92 | 62 | 16.0 | 100 |
| HI ≥ 40 | 66 (68) | 119 (100–142) | 119 (100–142) | 98 | 55 | 1.0 | 2 | 40 (75) | 141 (114–174) | 283 (227–354) | 100 | 95 | 2.0 | 23 |
| A/Texas/50/2012 (A/H3N2) | ||||||||||||||
| All | 97 (100) | 120 (96–151) | 131 (103–164) | 88 | 65 | 1.1 | 3 | 53 (100) | 118 (86–162) | 316 (250–400) | 98 | 91 | 2.7 | 34 |
| HI < 40 | 14 (14) | 16 (12–22) | 20 (15–26) | 84 | 52 | 1.2 | 0 | 6 (11) | 13 (7–26) | 151 (38–605) | 92 | 77 | 11.3 | 83 |
| HI ≥ 40 | 83 (86) | 168 (140–202) | 180 (149–218) | 89 | 71 | 1.1 | 4 | 47 (89) | 155 (120–201) | 347 (279–432) | 100 | 95 | 2.2 | 28 |
| B/Massachusetts/02/2012 (B/Yamagata) | ||||||||||||||
| All | 97 (100) | 61 (46–81) | 101 (81–125) | 87 | 54 | 1.6 | 18 | 53 (100) | 98 (73–132) | 304 (243–380) | 100 | 92 | 3.1 | 34 |
| HI < 40 | 29 (30) | 10 (8–13) | 36 (24–55) | 74 | 35 | 3.6 | 45 | 8 (15) | 16 (9–28) | 247 (114–533) | 100 | 100 | 15.3 | 88 |
| HI ≥ 40 | 68 (70) | 132 (108–161) | 155 (129–186) | 92 | 62 | 1.2 | 6 | 45 (85) | 135 (106–171) | 315 (248–401) | 100 | 90 | 2.3 | 24 |
| B/Brisbane/60/2008 (B/Victoria) | ||||||||||||||
| All | 97 (100) | 34 (27–44) | 53 (43–65) | 73 | 27 | 1.5 | 12 | 53 (100) | 36 (26–49) | 148 (115–190) | 98 | 64 | 4.1 | 53 |
| HI < 40 | 40 (41) | 0 (8–12) | 25 (18–34) | 52 | 19 | 2.4 | 25 | 21 (40) | 10 (8–13) | 96 (60–153) | 92 | 62 | 9.3 | 90 |
| HI ≥ 40 | 57 (59) | 81 (67–97) | 90 (75–108) | 83 | 30 | 1.1 | 4 | 32 (60) | 83 (68–100) | 197 (153–252) | 100 | 65 | 2.4 | 28 |
a
The influenza virus strain and prevaccine HI titer are shown for all vaccine recipients and for recipients with HI titers of <40 and ≥40.