Figure 2.

Effect of Ho FrIII (A) and Ho FrIV (B) on the chemical stimuli (formalin test). Ho FrIII and Ho FrIV (2.5, 5 or 10 mg/kg) or saline were given intravenous 30 min before the formalin, and the licking time was determined during the first 5 min (Phase I, [a]) and 20–25 min (Phase II, [b]) after a 1% formalin injection in rats. Data are expressed as the mean ± standard error of mean of six animals per group. *P < 0.05 indicates significant difference from the saline group. *,& Indicates significant difference from indomethacin-treated group (ANOVA, Tukey's test)