Table 2.

Pooled analysis of the diagnostic performance of magnetic resonance elastography for diagnosis and staging of liver fibrosis, based on 232 patients from 9 studies (6 independent cohorts).

Fibrosis Stage	Optimal cut- off (kPa)	AUROC (95% CI)	Sensitivity (95% CI)	Specificity	Positive LR	Negative LR
Any Fibrosis (≥Stage 1)	2.88	0.86 (0.82–0.90)	0.75 (0.68–0.87)	0.77 (0.65–0.88)	3.24	0.33
Significant Fibrosis (≥Stage 2)	3.54	0.87 (0.82–0.93)	0.79 (0.76–0.90)	0.81 (0.72–0.91)	4.14	0.27
Advanced Fibrosis (≥Stage 3)	3.77	0.90 (0.84–0.94)	0.83 (0.53–0.90)	0.86 (0.81–0.96)	5.93	0.19
Cirrhosis (Stage 4)	4.09	0.91 (0.76–0.95)	0.88 (0.82–1.00)	0.87 (0.77–0.97)	6.50	0.14

[Abbreviations: AUROC-Area under receiver-operating curve, CI-Confidence intervals, LR-likelihood ratio]