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Craniofacial and skin findings in Crouzonodermoskeletal syndrome. After successful cranioplasty to treat Kleeblatschaedel skull deformity, he has residual midfacial hypoplasia. Note periorbital and perioral acanthosis nigricans. This patient was found to have the classic FGFR3 (A319E) mutation of Crouzono-dermoskeletal syndrome. Reproducted with permission from Cunningham et al. [2].
