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. 2016 Oct 1;22:3506–3513. doi: 10.12659/MSM.900688

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© Med Sci Monit, 2016

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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UCA1 knockdown and miR-27b overexpression sensitizes MDR gastric cancer cells to chemotherapeutic agents. (A, B) ADR, DDP and 5-FU IC50 in SGC-7901/ADR cells after transfection of UCA1 siRNA (A) or miR-27b mimics (B). (C, D) Representative images (C) and quantitation (D) of flow cytometric analysis of apoptotic SGC-7901/ADR cells with the transfection of UCA1 siRNA or miR-27b mimics and then treated with 20 μg/mL ADR for 48 hours. (E) Western blot analysis BCL-2 and cleaved caspase-3 expression in SGC-7901/ADR cells with the transfection of UCA1 siRNA or miR-27b mimics and then treated with 20 μg/mL ADR for 48 hours. ** p<0.01.