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Factors controlling gene expression in cancer. The expression of the oncogene MYC is regulated by miRs gene expression (pink square, left), the availability of the miR-RISC (shown in blue), DNA-methylation promoter region (purple hexagon), and gene copy number abnormalities (duplicated copies of MYC shown as purple squares). MiR loading to RISC leads to targeting the 3′ UTR of the MYC mRNA, where it is degraded and translation by the ribosome is inhibited.
