Table 2.
Comparison of AUC values of training data set for single/combined marker(s) using logistic regression
| Marker | AUC | Probability | Sensitivity at 94% specificity (%) | Cutoff at 94% specificity |
|---|---|---|---|---|
| HE4 | 0.821 | 5.04E-51 | 51.43 | 0.1094199 |
| CEA | 0.753 | 1.78E-32 | 33.21 | 0.6434527 |
| RANTES | 0.858 | 1.02E-62 | 2.86 | 5.076444 |
| ApoA2 | 0.867 | 4.98E-66 | 0.71 | 5.60206 |
| TTR | 0.83 | 1.20E-53 | 1.43 | 5.630428 |
| sVCAM-1 | 0.552 | 0.0074418 | 6.07 | 3.161243 |
| CEA, HE4 | 0.855 | 6.12E-62 | 55.00 | 0.5850375 |
| RANTES, ApoA1, TTR, sVCAM-1 | 0.964 | 2.88E-104 | 84.29 | 0.4779614 |
| CEA, HE4, RANTES, ApoA2, TTR, sVCAM-1 | 0.983 | 2.03E-112 | 92.50 | 0.357278 |
| CEA, HE4, RANTES, ApoA2, TTR, sVCAM-1, age | 0.986 | 3.68E-114 | 93.21 | 0.3700928 |
AUC, the area under the curve; HE4, human epididymis secretory protein 4; CEA, carcinoembryonic antigen; RANTES, regulated on activation, normal T cell expressed and secreted; ApoA2, apolipoprotein A2; TTR, transthyretin; sVCAM-1, secretory vascular cell adhesion molecule-1.