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. 2016 Oct 5;11(10):e0162636. doi: 10.1371/journal.pone.0162636

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© 2016 Biswas, Longmore

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — SNAIL1 expression increases in mouse heart post LAD ligation. (A) Schematic representation of the SNAIL1-CBR targeting construct. E1,E2,E3 are the three exons of SNAIL1-CBR is clic beetle red bioluminescent protein. (B) The timeline of the experiment. (C) SNAIL1-CBR bioluminescence signal in sham (n = 3) and infarcted hearts (n = 4) after Left Anterior Descending Artery Occlusion (LAD). (D) Quantification of biolumincence signal in (C). (E) Relative level of SNAIL1 mRNA in LAD ventricles, normalized to SNAIL1 mRNA from sham treated ventricles, as determined by Q-PCR. SNAIL1 mRNA level in sham treated hearts was arbitrarily set to 1. (F) Relative mRNA levels for select fibrogenic genes, as indicated, in LAD ventricles normalized to sham treated ventricles. Determined by Q-PCR. SNAIL1 mRNA level in sham treated hearts was arbitrarily set to 1. Representative of 3 hearts. (G) Representative images of trichrome staining for collagen in Sham and LAD sections. All experiments were repeated three times with three mice (minimum) in each group.