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. 2016 Oct 5;11(10):e0164117. doi: 10.1371/journal.pone.0164117

Table 4. Genes consistently repressed by the 3 Borrelia strains with fold-change values ≤ 0.5.

Annotation B. afzelii (IBS 17) B. garinii (IBS 6) Bb ss (IBS 19) Description/Function
Fold change p-value Fold change p-value Fold change p-value Cell division process
CDC20 0,38 3,97E-06 0,35 1,53E-05 0,41 1,19E-04 Activator of the anaphase promoting complex (APC/C)
PBK 0,50 1,22E-05 0,50 6,95E-05 0,49 5,06E-04 PDZ binding kinase: related to mitogen-activated protein kinase (MAPKK) family
TOP2A 0,46 3,65E-06 0,44 8,88E-06 0,49 3,47E-04 DNA topoisomerase 2-alpha: role in mitosis and meiosis for proper segregation of daughter chromosomes
KIF20A 0,40 3,97E-05 0,37 3,21E-05 0,41 3,15E-05 Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis
UBE2C 0,37 1,10E-05 0,36 2,35E-05 0,37 9,67E-05 Ubiquitin-conjugating enzyme E2 C: essential factor of the anaphase promoting complex/cyclosome (APC/C)
CEP55 0,49 1,39E-04 0,47 7,27E-05 0,48 1,72E-03 Centrosomal protein of 55 kDa: role in mitotic exit and cytokinesis
LOC399942 0,44 3,17E-03 0,48 7,97E-03 0,49 2,20E-02 Predicted: similar to Tubulin alpha-2 chain, major constituent of microtubules
ASPM 0,46 8,55E-06 0,44 5,35E-05 0,48 6,88E-05 Probable role in mitotic spindle regulation and coordination of mitotic processes
LOC100132394 0,36 8,45E-04 0,44 8,59E-03 0,36 4,50E-03 Unknown function