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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: N Engl J Med. 2014 Jan 30;370(5):486–488. doi: 10.1056/NEJMc1304828

Figure 1. Sequential Magnetic Resonance Images of the Brain.

Figure 1

When the patient presented for treatment, axial fluid-attenuated inversion recovery images showed multilobar progressive multifocal leukoencephalopathy (Panels A and B). A T1-weighted image after gadolinium infusion showed frank immune reconstitution inflammatory syndrome (IRIS) after the patient discontinued maraviroc (Panel C).

After the patient began to receive maraviroc again, a T1-weighted image after gadolinium infusion showed regression of IRIS (Panel D). A T1-weighted image after gadolinium infusion obtained 2 months after gradual discontinuation of maraviroc showed stable lesions with no enhancement (Panel E).