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Mean (±SEM) breakpoints reached by mephedrone-trained rats under the progressive ratio procedure following training under Long Access (N=7) and Short Access (N=8) conditions. The top panel includes breakpoints during mephedrone (4-MMC) dose substitution. The bottom panel includes data from methamphetamine (MA) substitution. Significant differences from vehicle control are indicated by *, from the highest dose by # and differences between LgA and ShA groups are indicated by †.
