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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Pediatr Crit Care Med. 2016 Oct;17(10):968–975. doi: 10.1097/PCC.0000000000000900

Table 2.

Dosing (median, IQR) of midazolam and pentobarbital for RSE

Dosing Midazolam Pentobarbital
Bolus dose 0.11 (0.09 – 0.22) mg/kg 3.7 (0.6 – 5.2) mg/kg
Initial infusion rate 0.10 (0.06 – 0.23) mg/kg/hr
(or 1.7 [1.0 – 3.8] mcg/kg/min)		 1.0 (1.0 – 2.0) mg/kg/hr
Highest subsequent infusion rate in responders 0.10 (0.06 – 0.50) mg/kg/hr
(or 1.7 [1.0 – 8.3] mcg/kg/min)		 3.0 (1.5 – 4.0) mg/kg/hr
Highest subsequent infusion rate in non-responders 0.20 (0.20 – 1.5) mg/kg/hr
(or 3.3 [3.3 – 25.0] mcg/kg/min)