Table E6.
Adjusted associations of wheezing phenotypes at 0 to 16½ years with presalbutamol lung function measures at 15 years (z scores) in participants with at least 2 observations of wheeze
| Wheezing phenotype at 0-16½ y | FEV1 (SDU) at 15 y |
FVC (SDU) at 15 y |
FEV1/FVC ratio (SDU) at 15 y |
FEF25-75 (SDU) at 15 y |
||||
|---|---|---|---|---|---|---|---|---|
| No.∗ | Adjusted mean difference (95% CI)† | No.∗ | Adjusted mean difference (95% CI)† | No.∗ | Adjusted mean difference (95% CI)† | No.∗ | Adjusted mean difference (95% CI)† | |
| Never/infrequent wheeze | 2,064 | 0 (reference) | 2,092 | 0 (reference) | 2,064 | 0 (reference) | 2,091 | 0 (reference) |
| Preschool-onset remitting wheeze | 473 | −0.06 (−0.16 to 0.03) | 477 | 0.05 (−0.05 to 0.14) | 473 | −0.21 (−0.31 to −0.12) | 476 | −0.16 (−0.25 to −0.06) |
| Midchildhood-onset remitting wheeze | 207 | −0.03 (−0.17 to 0.11) | 209 | 0.16 (0.02 to 0.30) | 207 | −0.35 (−0.49 to −0.22) | 209 | −0.25 (−0.39 to −0.11) |
| School-age–onset persisting wheeze | 129 | −0.16 (−0.33 to 0.02) | 131 | 0.08 (−0.10 to 0.25) | 129 | −0.45 (−0.62 to −0.28) | 131 | −0.40 (−0.57 to −0.22) |
| Late childhood–onset persisting wheeze | 135 | −0.20 (−0.36 to −0.03) | 135 | −0.04 (−0.21 to 0.13) | 135 | −0.29 (−0.45 to −0.13) | 135 | −0.33 (−0.50 to −0.17) |
| Continuous wheeze | 128 | −0.23 (−0.41 to −0.04) | 130 | 0.04 (−0.14 to 0.22) | 128 | −0.54 (−0.72 to −0.37) | 130 | −0.53 (−0.71 to −0.35) |
∗
Number of participants with data available (approximated from modal assignment).
†
Adjusted for sex, parity, maternal history of asthma or allergy, maternal smoking and anxiety during pregnancy, preterm delivery, low birth weight, and day care attendance during first year.