Table E7.
Adjusted associations of wheezing phenotypes at 0 to 16½ years with lung function measures at 15 years (presalbutamol z scores) further adjusted by lung function measures at 8 years (presalbutamol z scores) in participants with at least 2 observations of wheeze
| Wheezing phenotype at 0-16½ y | FEV1 (SDU) at 15 y |
FVC (SDU) at 15 y |
FEV1/FVC ratio (SDU) at 15 y |
FEF25-75 (SDU) at 15 y |
||||
|---|---|---|---|---|---|---|---|---|
| No.∗ | Adjusted mean difference (95% CI)† | No.∗ | Adjusted mean difference (95% CI)† | No.∗ | Adjusted mean difference (95% CI)† | No.∗ | Adjusted mean difference (95% CI)† | |
| Never/infrequent wheeze | 1,784 | 0 (reference) | 1,826 | 0 (reference) | 1,743 | 0 (reference) | 1,825 | 0 (reference) |
| Preschool-onset remitting wheeze | 415 | 0.02 (−0.08 to 0.11) | 422 | 0.08 (−0.01 to 0.17) | 407 | −0.16 (−0.25 to −0.07) | 421 | −0.03 (−0.12 to 0.06) |
| Midchildhood-onset remitting wheeze | 183 | 0.08 (−0.05 to 0.22) | 187 | 0.17 (0.04 to 0.31) | 179 | −0.22 (−0.36 to −0.09) | 187 | −0.02 (−0.15 to 0.11) |
| School-age–onset persisting wheeze | 110 | −0.05 (−0.22 to 0.13) | 113 | 0.11 (−0.06 to 0.28) | 110 | −0.33 (−0.50 to −0.16) | 113 | −0.19 (−0.36 to −0.03) |
| Late childhood–onset persisting wheeze | 117 | −0.07 (−0.24 to 0.09) | 118 | 0.02 (−0.14 to 0.18) | 117 | −0.21 (−0.37 to −0.05) | 118 | −0.17 (−0.32 to −0.01) |
| Continuous wheeze | 106 | −0.04 (−0.22 to 0.14) | 110 | 0.06 (−0.12 to 0.23) | 103 | −0.25 (−0.42 to −0.07) | 110 | −0.14 (−0.31 to 0.03) |
∗
Number of participants with data available (approximated from modal assignment).
†
Adjusted for sex, parity, maternal history of asthma or allergy, maternal smoking and anxiety during pregnancy, preterm delivery, low birth weight, and day care attendance during first year and additionally for lung function at 8 years.