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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Small. 2016 Apr 7;12(20):2750–2758. doi: 10.1002/smll.201502930

Figure 4.

Figure 4

Transmission electron microscopy of polyplexes form by S-22 interacting with HeLa cells, including overview (A), endocytosis (B), entrapped in endosome (C) and locating in cytoplasm (D). HeLa cells were treated with polyplexes for 1 h prior to fixation and preparation for TEM. Scale bar indicates 200 nm. (E) Unpacking study of polyplexes (N/P = 5) in the absence and presence of heparin sulfate (5 μg/mL). Data are shown as mean ± SD (n = 3; student's t-test, *p < 0.05, **p < 0.01, ***p < 0.001).