Figure 3.

Schematic representations of the real-time protocols. The code-driven closed-loop protocol is described by the scheme (A). The open-loop stimulation protocol used as a comparison is described by the scheme (B). In both, the green box represents the entry point and the red box represents the exit point. Each function is executed on every real-time interval (time = t) and starts acquiring the value of the monitored signal (V). The trigger “Stimulate?” in both protocols depends on the pulse-stimulus delay (fixed value or range) introduced as a parameter to the protocol.